Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes.
نویسندگان
چکیده
Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.
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عنوان ژورنال:
- Journal of virology
دوره 73 5 شماره
صفحات -
تاریخ انتشار 1999